Acute myeloid leukaemia (AML)
Acute myeloid leukaemia is a malignant disease of the hematopoietic system, affecting mainly adults above 60 years of age. In Germany, about 3,600 incidences are registered annually. AML is caused by uncontrolled growth of dysfunctional hematopoietic precursor cells in the bone marrow. These cells prevent the generation of normal blood cells, causing a drop in erythrocytes and platelets, for example. Typical symptoms of AML include anemia, fever, increased risk of infection, and blood coagulation disorder. AML progresses rapidly and may be fatal within a few weeks if untreated.
AML is treated initially with intensive chemotherapy. Another treatment option is allogeneic hematopoietic stem cell transplantation. Unfortunately, the majority of patients suffer a relapse. Only about 15 - 20 % of the patients show long-term remission after conventional chemotherapy. Allogeneic hematopoietic stem cell transplantation is the only treatment option that offers a more positive prognosis.
Multiple Myeloma (MM)
Multiple Myeloma (MM) is a cancer of plasma cells, characterized by monoclonal plasma cell proliferation in the bone marrow. According to WHO criteria, it is a B-cell lymphoma associated malignant disease with increased production of complete or incomplete monoclonal immunoglobulins. These proteins are detectable in serum and/or urine. Each year, in Germany, about 3,000 men and 2,700 women are newly diagnosed with multiple myeloma (ICD10 C90). MM is the third most common hematologic malignancy after leukemia and non-Hodgkin's lymphoma, accounting for around 1% of all cancers in Germany.
Genital warts are benign tumors caused by infection with certain human papillomaviruses (HPV). They disfigure the genital and anal areas, and may be associated with discomfort, including itching, a burning sensation, discharge, bleeding and pain. Genital warts are one of the fastest spreading sexually transmitted diseases. An estimated 30 million people are affected worldwide. Treatment is not only recommended to reduce discomfort, but also to prevent worsening of the disease and infection of sexual partners. Depending on anatomic location and size, various surgical and drug-based treatment methods are available. Alongside the conservative removal of existing warts, stopping warts from recurring is a key treatment objective.