CUTTING EDGE
TECHNOLOGies

Medigene focuses on the development of living immunotherapies to treat different types of cancer. Living immunotherapies are treatments based on living cells made from a patient’s own immune cells.  

Until the 1990s physicians relied primarily on three approaches to treat cancer: removal of tumors by surgery, or killing of tumor cells by chemotherapy or radiation, or a mixture of these treatments. These classical non-targeted therapies generally lead to a considerable improvement in illness initially, but this improvement is often short-lived and such treatment is often unable to stop the progression of cancer. In addition, patients suffer serious and significant side effects when undergoing these treatments.

Unfortunately, it is usually impossible to completely stop progressive growth of cancer that may have already spread at the time of diagnosis. In the past several decades, new therapies such as hormone therapies, anti-angiogenesis approaches and manipulation of signal transduction pathways in cancer cells were developed that represent more targeted approaches that can lead to improved success in cancer treatment with better tolerability for patients.

Cancer arises from genetic mutations that accumulate in cells which lead to uncontrolled cell growth and prevent or impede the ability of the immune system to recognize and combat this process. The tremendous increase in knowledge on how the human immune system functions over the last two decades and subsequent opportunities to directly influence it in a specific way have resulted in innovative treatment strategies for cancer, which all come under the umbrella term of immunotherapy. These innovative immunotherapies serve to activate, influence, and optimize the natural capacities of the immune system of a patient to more effectively combat cancer. Empowering the patient’s own immune cells is crucial to achieve long lasting benefit and to provide the potential to cure their cancer.

T cells play a major role in the immune response of humans. These cells in the immune system are ultimately effector cells which directly combat, kill and eliminate tumor cells. The specific activation, stimulation, strengthening and improvement of T cell-specificity is a modern therapy approach which should allow for effective, long-lasting treatment of cancer.

Empowering the immune system with cutting edge technologies

Medigene develops three complementary immunotherapies to mobilize the powerful capacities of the T cell to fight cancer.

T cells play a major role in the immune response of humans. These cells in the immune system are ultimately effector cells which directly combat, kill and eliminate tumor cells. The specific activation, stimulation, strengthening and improvement of T-cell specificity is a modern therapy approach with the aim of enabling an effective, long-lasting treatment of cancer.

TCR-Ts

Generating large numbers of cancer-specific T cells to treat large tumor burdens. 

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DCs

An entirely new generation of DC vaccines is being developed.

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TABs

Developing monoclonal antibodies to recognize T cells. 

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Immune Monitoring Facility

Medigene has established its own immune monitoring facility, which represents an integrated technology platform deeply linked with our other complementary immunotherapy platforms.

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INTELLECTUAL PROPERTY

Medigene’s proprietary TCR platform technology for the identification and selection of natural TCRs is protected by exclusively in-licensed patents in Europe, the US and Japan. All TCRs generated by our proprietary TCR platform technology are individually protected by patent rights in countries selected on the basis of our corporate commercial long term strategy.

Medigene is constantly developing improved methods for the efficient and fast identification of tumor-antigen specific T-cell receptors, with these methods are also subject for new patent protection in-line with our company patent strategy.

Our DC platform is protected by exclusively in-licensed patents in Europe, the US and Australia covering methods for maturation of DCs and resulting dendritic cells with further pending applications in Europe, US and Canada.

In addition, our patent-portfolio for the DC technology comprises patent rights in Europe and the US, claiming a method for the generation of HLA-haplo-identical antigen-presenting cells for the treatment of tumor diseases which gives us additional protection for our DC technology in the field of treatment of patients with minimal residual diseases in the setting of haplo-identical bone-marrow and stem cell transplantation.

Advances in our DC technology are expected to generate additional IP protection for this platform.

The TABS technology platform comprises intellectual property claiming the method for generating TABS (T-cell receptor-specific antibodies) and specific TABS.

latest publications

Subklewe M., Geiger C., Lichtenegger F.,  Javorovic M., Kvalheim G., Schendel D.J., Bigalke I. 2014. New generation dendritic cell vaccine for immunotherapy of acute myeloid leukemia. Cancer Immunology. 10.1007/s00262-014-1600-5

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Lichtenegger, F. S., Mueller, K., Otte, B., Beck, B., Hiddemann, W.,  Schendel, D. J. and M. Subklewe. 2012. CD86 and IL-12p70 are key players for T helper 1 polarization and natural killer cell activation by Toll-like receptor-induced dendritic cells. PLoS One. 7(9): e44266.

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